HemoTypeSC detects hemoglobin A, hemoglobin S, and hemoglobin C using highly specific monoclonal antibodies. Therefore, six different hemoglobin phenotypes can be resolved: HbAA, HbAS, HbAC, HbSS, HbSC, and HbCC.
HemoTypeSC is blind to fetal hemoglobin, meaning that even samples with very high HbF (i.e. from newborns with >95% HbF content) can be accurately screened.
HemoTypeSC is a competitive lateral flow immunoassay. The hemoglobin in the blood sample “competes away” the corresponding test line on the test strip. Therefore, a missing line means a positive result for that particular hemoglobin. HemoTypeSC may be used to screen individuals of all ages and is ideal for screening newborns. Each monoclonal antibody in HemoTypeSC is highly sensitive for its respective hemoglobin and is blind to fetal hemoglobin.