* Prevent stroke and systemic blood clots in people with non-valvular atrial fibrillation.
* Treat deep-vein thrombosis (DVT) — a blood clot, usually in the leg.
* Treat pulmonary embolism (PE) — a blood clot that has traveled to the lungs.
* Prevent recurrent DVT or PE after initial treatment.
* Prevent DVT after hip or knee replacement surgery.
* Reduce certain cardiovascular clot-related risks in people with coronary artery disease (CAD) or peripheral artery disease (PAD),