The main over-the-counter wart removal creams use salicylic acid, which works by peeling away layers of the wart over weeks, often with brands like Compound W or Dr. Scholl's, requiring you to soak the wart and file dead skin before applying. Other options include freezing sprays, while prescription creams (like Imiquimod) or treatments for sensitive areas (genitals/face) should be discussed with a doctor, as salicylic acid isn't safe there.